Adding a certain compound to certain chemical reactions, such as: 1871-57-4, name is 3-Chloro-2-chloromethyl-1-propene, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1871-57-4, SDS of cas: 1871-57-4
[0129] A mixture of BnNH-L-Asp(Otbutyl)-Obn from step 1a (12.1 g, 32.6 mmol), K2CO3 (14 g, 3 eq.), NaI (3.0 g, 20mmol) and 1-chloro-2-chloromethyl-1-propene (5.1 g, 40.8 mmol) in MeCN (150 mL) was stirred at 81 C for 16 h. Aftercooling, the mixture was filtered. The filtrate was concentrated and purified by Combiflash (hexane and ethyl acetate:gradient 0 to 8% during 12 min) to give (8.7 g) 1-benzyl 4-tert-butyl (2S)-2-{benzyl[2-(chloromethyl)prop-2-en-1-yl]amino}succinate, MS (ESI): 458.3/460.3 (M + H+).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-Chloro-2-chloromethyl-1-propene, and friends who are interested can also refer to it.
Reference:
Patent; Incyte Corporation; YAO, Wenqing; ZHOU, Jincong; XU, Meizhong; ZHANG, Fenglei; METCALF, Brian; EP1622569; (2015); B1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics