Electric Literature of 174913-12-3, A common heterocyclic compound, 174913-12-3, name is 1-Bromo-3-chloro-5-methoxybenzene, molecular formula is C7H6BrClO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Preparation 3 [3-CHLORO-5-METHOXVBENZONITRILE] Tetrakis (triphenylphosphine) palladium (0) (174 mg, 0.15 [MMOL)] was added in one portion to a stirred solution of the bromide of Preparation 1 (500 mg, 2.26 [MMOL)] and zinc cyanide (146 mg, 1.24 [MMOL)] [IN N, N-DIMETHYLFORMAMIDE] (3 ml) at room temperature under a nitrogen atmosphere. The reaction was heated at [100C] for 14 hours and then cooled to room temperature. The solvent was evaporated under reduced pressure and the residue was purified by chromatography on silica gel using ethyl acetate in cyclohexane as eluant (5: 95) to provide the title compound as a yellow oil (380 mg).1H-NMR [(300MHZ,] [CDC13)] : [8 3.] 82 (s, 3H), 7.04 (s, [1H),] 7.12 (s, [1H),] 7.23 (s, 1H).
The synthetic route of 174913-12-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; PFIZER LIMITED; PFIZER INC.; WO2004/31178; (2004); A1;,
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