In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Chloro-5-methylaniline, other downstream synthetic routes, hurry up and to see.
Related Products of 95-81-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 95-81-8, name is 2-Chloro-5-methylaniline belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
Example 2A 10.0 g (70.6 mmol) of 2-chloro-5-methyl-aniline were dissolved in 38 ml hydrochloric acid (20% in water). At -5C a solution of 5.36 g (77.7 mmol) of sodium nitrite in 70 ml water was added drop wise within 40 min and kept at this temperature for further 30 min. The cold solution was added drop wise to a solution of 40.2 g (178 mmol) of tin(ll)-chlohde dihydrate in 48 ml of hydrochloric acid (32% in water), maintaining the temperature at -100C. The resulting suspension was heated to 25C and stirred for 12 h. The suspension was cooled to 00C and 350 ml sodium hydroxide (40% in water) were added. The solution was extracted with ethyl acetate three times. The organic layers were collected, extracted with water and dried over magnesium sulphate. Filtration and evaporation of the solvent under reduced pressure yielded the hydrazine as a solid. (9.6 g, 87% of theory).HPLC-MS (Method 1 ): RT: 0.90 minMS (ESI pos): m/z = 157/159 (Cl) (M+H)+ and 140/142 (Cl) (M-NH3+H)+.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Chloro-5-methylaniline, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; WO2009/68617; (2009); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics