Application of 1435-48-9, A common heterocyclic compound, 1435-48-9, name is 2,4-Dichloro-1-fluorobenzene, molecular formula is C6H3Cl2F, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a solution of 2,4-Dichloro-1-fluorobenzene (8.0 g, 48.5 mmol) in THF (63 mL) n-BuLi (23.27 mL, 2.5 M, 43.6 mmol) was added dropwise at -78 C and stirred for 1.5 h. To the mixture Sulfur (3.1 g, 72.7 mmol) was added at -78 C and stirring for 2 h. To the resulting mixture 10% Hydrochloric acid (HCl) was added to adjust pH to 5-6. The resulting mixture was extracted with EtOAc (200 mL * 3), the combined organic phase was washed with brine (100 mL * 2), dried over Na2SO4. After filtered, the organic phase was concentrated to dry to give compound 31 as yellow oil (11.4 g, 99.0% yield). 1H NMR (400 MHz, CDCl3) delta 7.31-7.19 (m, 1H, Ar-H), 6.95-6.89 (t, 1H, Ar-H), 4.69 (s, 1H, SH).
The synthetic route of 1435-48-9 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Liu, Na; Wang, Yanfen; Huang, Gongchao; Ji, Conghui; Fan, Wei; Li, Haitao; Cheng, Ying; Tian, Hongqi; Bioorganic Chemistry; vol. 65; (2016); p. 146 – 158;,
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