Related Products of 41965-95-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 41965-95-1 name is 3-Chloro-4-methoxybenzylamine Hydrochloride, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
General procedure N: Amide coupling (10):In a glass vial, under inert atmosphere (N2), to a solution of the carboxylic acid (1.0 eq.) in CH2CI2 (0.25 M) were added HOBt (1.20 eq.), DMAP (0.25 eq.), EDC HCI (2.5 eq.) and DIPEA (4.0 eq.). The reaction mixture was stirred at rt for 30 min. An amine (2.0 eq.) was then added and the reaction mixture stirred at rt until completion of the reaction. DMF (0.3 vol. CH2CI2) and PL-SO2CI2 (1.0 eq.) were added and after stirring at rt for 1 h the mixture was filtered (CH2CI2) and concentrated under reduced pressure. Purification of the residue by FC or HPLC gave the desired compound.; Example 374:(Sf^-Lambda/^S-Chloro^-methoxyphenyl-methyO-tef^-Lambda^^-pyrrolidino-butyO^S*^/?*)- [4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide, formate salt:Following general procedure N, starting from (5R*)-5-hydroxycarbonyl-(6R*)-Lambda/6-(4- pyrrolidin-1-yl-butyl)-(4S*,7/?*)-[4,7-ethenylene-spiro[2.4]heptane]-6-carboxamide and 3- chloro-4-methoxybenzylamine hydrochloride.LC-MS-conditions FA: tR = 0.75 min; [M+H]+ = 486.24.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-Chloro-4-methoxybenzylamine Hydrochloride, and friends who are interested can also refer to it.
Reference:
Patent; ACTELION PHARMACEUTICALS LTD; BUR, Daniel; CORMINBOEUF, Olivier; CREN, Sylvaine; GRISOSTOMI, Corinna; LEROY, Xavier; RICHARD-BILDSTEIN, Sylvia; WO2010/134014; (2010); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics