Synthetic Route of 29671-92-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 29671-92-9, name is Carbamimidic chloride hydrochloride, This compound has unique chemical properties. The synthetic route is as follows.
Chloroformamidine hydrochloride with Sodium hydroxide is put into A 25 mL round bottom flask was charged with 3 mL of acetonitrile solvent and pretreated Neutralize the acid, get free amidine. Then, ethyl benzoylacetate and perfluoroiodobutane were successively added at room temperature. indoor Light and room temperature for 8h, TLC monitoring reaction end, stop the reaction, the mixture. [0119] Ethyl benzoylacetate: Perfluorooiodobutane: Chloroformamidine hydrochloride: Sodium hydroxide = 1.0: 1.1: 1.1: 4.1; [0120] 2. The mixture was extracted three times with water, the organic phases were combined and the organic solvent was removed by distillation under reduced pressure to give crude product. [0121] 3. The crude product was chromatographed on silica gel eluting with eluent (petroleum ether: ethyl acetate = 30: 1 (nu: nu) A white solid was obtained as the product ethyl-2-chloro-4-perfluoropropyl-6-phenylpyrimidine-5-carboxylate in 57% yield.
The chemical industry reduces the impact on the environment during synthesis Carbamimidic chloride hydrochloride. I believe this compound will play a more active role in future production and life.
Reference:
Patent; Liaoning University; Liang Fushun; Wang Rui; Han Zhengbo; Su Zhongmin; (12 pag.)CN106831603; (2017); A;,
Chloride – Wikipedia,
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