Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 108-70-3, name is 1,3,5-Trichlorobenzene, A new synthetic method of this compound is introduced below., COA of Formula: C6H3Cl3
Example 1; Method A-1; Preparation 2-bromo-1-(2, 4, 6-trichlorophenyl) ethanone; A mixture of 1,3, 5-trichlorobenzene (10.0 g, 55.1 mmol), 2-bromoacetyl bromide (5.0 mL, 57.8 mmol, 1.05 eq), and aluminum chloride (7.7 g, 57.8 mmol, 1.05 eq) was heated neat at 80 C under argon for 17 h until a black precipitate is formed. The reaction was cooled to room temperature, and the resultant black mass was dissolved in ethyl acetate (500 mL). Water (200 mL) was added slowly at 0 C to quench the reaction, and the biphasic layers were separated. The organic layer was then washed with water (2 x 150 mL) and brine (1 x 150 mL), dried (MgS04), filtered, and evaporated in vacuo. Recrystallization from hexane gave 11.5 g (69.3%) of 2-bromo-1-(2, 4, 6-trichlorophenyl)- ethanone as a fluffy white solid. 1H-NMR (DMSO-d6) 6 7.86 (s, 2H), 4.78 (s, 2H); Rf = 0.28, 2% ethyl acetate-hexane.
The synthetic route of 108-70-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BAYER PHARMACEUTICALS CORPORATION; WO2003/72561; (2003); A1;,
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