Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 57310-39-1, name is 3-Bromo-4-chlorotoluene, A new synthetic method of this compound is introduced below., Quality Control of 3-Bromo-4-chlorotoluene
General procedure: A mixture of bromotoluene intermediate 7-14 or 16 (10 mmol), N-bromosuccinimide (15 mmol, 2.67 g) and azobisisobutyronitrile (5 mmol, 82 mg) in tetrachloromethane (20 mL) was refluxed for 16 h. After cooling the mixture was filtered, the filtrate was diluted with dichloromethane (30 mL), washed with water (50 mL) and brine (50 mL), dried over anhydrous Na2SO4 and evaporated. The residue containing the adequate benzyl bromide derivative without further purification was used to the next step.
The synthetic route of 57310-39-1 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Szyma?ska, Ewa; Cha?upnik, Paulina; Szczepa?ska, Katarzyna; Cunado Moral, Ana Maria; Pickering, Darryl S.; Nielsen, Birgitte; Johansen, Tommy N.; Kie?-Kononowicz, Katarzyna; Bioorganic and Medicinal Chemistry Letters; vol. 26; 22; (2016); p. 5568 – 5572;,
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