Related Products of 6775-78-6, A common heterocyclic compound, 6775-78-6, name is 6-Chloroimidazo[1,2-b]pyridazine, molecular formula is C6H4ClN3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A mixture of 6-chloroimidazo[1,2-b]pyridazine (3) 19 (768 mg, 5.0 mmol), 4-aminophenol (818 mg, 7.5 mmol), and K2CO3 (2073 mg, 15.0 mmol) in NMP (5 mL) was stirred at 120 C for 18 h. The mixture was diluted with 1 N aqueous NaOH and extracted with EtOAc. The organic layer was washed with 1 N aqueous NaOH and brine and concentrated in vacuo. The residue was purified by basic silica gel column chromatography (hexane/EtOAc 70:30 to 0:100) and triturated with diisopropyl ether to give 4a (759 mg, 67%) as a gray solid. 1H NMR (DMSO-d6) delta 5.07 (2H, s), 6.60 (2H, d, J = 8.9 Hz), 6.92 (2H, d, J = 8.9 Hz), 7.00 (1H, d, J = 9.8 Hz), 7.61 (1H, s), 8.01 (1H, s), 8.09 (1H, d, J = 9.8 Hz).
The synthetic route of 6775-78-6 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Miyamoto, Naoki; Oguro, Yuya; Takagi, Terufumi; Iwata, Hidehisa; Miki, Hiroshi; Hori, Akira; Imamura, Shinichi; Bioorganic and Medicinal Chemistry; vol. 20; 24; (2012); p. 7051 – 7058;,
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