These common heterocyclic compound, 39191-07-6, name is 1-(3-Chlorophenyl)-N-methylmethanamine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Quality Control of 1-(3-Chlorophenyl)-N-methylmethanamine
Diisopropylethylamine (0.073 mL, 0.42 mmol) was added to a mixture of 3-[(2-methoxy-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carbonyl)-amino]-4-methyl-benzoic acid (0.05 g, 0.14 mmol) (from Example 20 supra) and HATU (0.080 g, 0.21 mmol) (Aldrich) in DMF (2.0 mL). The resulting mixture was stirred at room temperature for 30 minutes. 3-Chloro-N-methylbenzylamine (0.061 mL, 0.42 mmol) (Aldrich) was added. The mixture was stirred for 18 hours. The mixture was partitioned between ethyl acetate and water. The precipitate formed was collected by filtration and washed with methanol and dried in vacuum oven to give 2-methoxy-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid {5-[(3-chloro-benzyl)-methyl-carbamoyl]-2-methyl-phenyl}-amide. (Yield 0.018 g, 26.1%).HR-MS (ES+) m/z Calculated for C25H23ClN5O4 ([M+H]+): 514.1252. Found: 514.1251.
The synthetic route of 1-(3-Chlorophenyl)-N-methylmethanamine has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Anderson, Kevin; Chen, Yi; Chen, Zhi; Luk, Kin-Chun; Rossman, Pamela Loreen; Sun, Hongmao; Wovkulich, Peter Michael; US2012/184542; (2012); A1;,
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