Reference of 823-57-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 823-57-4, name is 2-Bromo-5-chloroaniline belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
HCl (500ml) for 2-bromo-5-chloroaniline (50 g, 242.16 mmol) and the mixture stirred at 0 while NaNO2 (17.5g, 253.62 mmol) to H2O (50ml) was added dropwise dissolved in a -10 after 1 hour It was stirred. The KI (44.2g, 266.26mmol) was stirred was dropwise added, dissolved in H2O (50ml) one hour at 0 . After completion of the reaction with ethyl acetate and filter the solidExtracts were dried over MgSO4 and the organic layer was filtered under reduced pressure. The filtered organic layer was evaporated under reduced pressure to a rear purified by column chromatography to the desired compound 1-bromo-4-chloro-2-iodobenzene (62 g,Yield: 66%) was obtained.
The synthetic route of 2-Bromo-5-chloroaniline has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Doosan Corporation; Kim, Tae Hyung; Bae, Hyung Chan; Lee, Chang Jun; Sin, Jin Yong; Jo, Hyun Chong; Baek, Young Mi; Rah, Jong Gyu; Park, Ho Chul; (46 pag.)KR2015/8658; (2015); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics