In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 61881-19-4 as follows. Computed Properties of C8H5ClF3N
X4 – 4 (594 mg, 1 mmol), N – benzene three fluorine second grades acyl chloride (0.45 ml, 3 mmol, 3 eq) dissolved in 8 ml of acetone, in batches adding potassium carbonate (410 mg, 3 mmol, 3 eq), stirring at room temperature 1 hour (TLC detection consumption end), filtering, the filtrate turns on lathe does, column to obtain white solid (601 mg, yield 79%)
According to the analysis of related databases, 61881-19-4, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Shanghai Pharmaceutical Industry Institute; China Pharmaceutical Industry Zongyuan; Lin Feng; Lu Rui; Xu Qiulong; Chen Jianli; Han Jine; (33 pag.)CN104231009; (2017); B;,
Chloride – Wikipedia,
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