Related Products of 870-24-6,Some common heterocyclic compound, 870-24-6, name is 2-Chloroethanamine hydrochloride, molecular formula is C2H7Cl2N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: Benzenesulfonyl chloride(525 mg, * 380 lL, 3 mmoL) was gradually added to a50-mL round-bottom flask containing 2-chloroethylamine.HCl (116 mg, 3 mmol) in dimethyl formamide(5 mL) and triethylamine (TEA, 500 lL). The reaction mixture was stirred at room temperature for 3 h and then poured into a cold solution of HCl 5 % (50 mL). The precipitate was collected and dried under vacuum at 40C to give compound 2a, which was used for the next step without further purification.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Chloroethanamine hydrochloride, its application will become more common.
Reference:
Article; Thuan, Nguyen Thi; Dung, Do Thi Mai; Que, Do Nguyet; Dung, Phan Thi Phuong; Vu, Tran Khac; Hahn, Hyunggu; Han, Byung Woo; Kim, Youngsoo; Han, Sang-Bae; Nam, Nguyen-Hai; Medicinal Chemistry Research; vol. 24; 11; (2015); p. 3803 – 3812;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics