Application of 5719-08-4, These common heterocyclic compound, 5719-08-4, name is 4-Chloro-9H-pyrimido[4,5-b]indole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: To a 100 mL round bottom flask were added appropriate 4-chloro-pyrimido[4,5-b]indole 11 or 12 (1 equivalent), 4-methoxy-N-methylaniline (4 equivalents), conc. HCl (2 drops), and BuOH (25 mL). The reaction mixture was heated to reflux for 72 h. After cooling to rt, silica gel (500 mg) was added, and BuOH was removed under reduced pressure to afford a silica gel plug. The plug was transferred on top of a column packed with silica gel, 20 times the weight of plug, and was eluted with 0.5% and 1% MeOH in CHCl3. Fractions containing the product (TLC) were pooled, and the solvent was evaporated to afford target compounds 2 or 3.
Statistics shows that 4-Chloro-9H-pyrimido[4,5-b]indole is playing an increasingly important role. we look forward to future research findings about 5719-08-4.
Reference:
Article; Devambatla, Ravi Kumar Vyas; Li, Wei; Zaware, Nilesh; Choudhary, Shruti; Hamel, Ernest; Mooberry, Susan L.; Gangjee, Aleem; Bioorganic and Medicinal Chemistry Letters; vol. 27; 15; (2017); p. 3423 – 3430;,
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