Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 694-80-4, name is 1-Bromo-2-chlorobenzene, A new synthetic method of this compound is introduced below., Safety of 1-Bromo-2-chlorobenzene
Sub 1-I-I-32 (109.66 g, 543.8 mmol) obtained in the above-Was placed in a round bottom flask,1-bromo-2-chlorobenzene (156.17 g, 815.7 mmol)And K2CO3 (225.48 g, 1,631.4 mmol)And copper (3.46 g, 54.4 mmol),Then, dibenzo 18-crown-6 (9.80 g, 27.2 mmol) was added thereto,nitrobenzene (2,700 mL) to 220 DEG C, and the reaction mixture is stirred for 24 hours.When the reaction is terminated, the reaction is filtered through silicagel filterAfter the reaction mixture was quenched with water, the water in the reaction mixture was removed,After filtration under reduced pressure,Dried over MgSO4 and concentrated. The resulting compound was purified by silicagel column and recrystallized to obtain 127.33 g (yield: 75%) of the product.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Duksan Neolux Co.,Ltd.; Yoon Jin-ho; Jeong Ho-yeong; Park Mu-jin; Kim Jeong-seok; Lee Seon-hui; (46 pag.)KR2018/128292; (2018); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics