Adding a certain compound to certain chemical reactions, such as: 883499-24-9, name is 1-Bromo-2-chloro-3-fluorobenzene, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 883499-24-9, Application In Synthesis of 1-Bromo-2-chloro-3-fluorobenzene
Under nitrogen environment,And at reflux temperature, 7-(diphenylamino)-9,9′-dimethyl-9H-fluoren-3-ol (100 g),1-bromo-2-chloro-3-fluorobenzene (58.3 g),The flask of potassium carbonate (91.5 g) and NMP (500 ml) was heated and stirred for 4 hours.After the reaction stopped, the reaction solution was cooled to room temperature, and water was added,The precipitate deposited was extracted by suction filtration. Use water in turn,After washing the obtained precipitate with methanol,Refined with silicone tubing (dissolved solution: toluene),Thus, 6-(3-bromo-2-chlorophenoxy)-9,9-dimethyl-N,N-diphenyl-9H-fluoren-2-amine (150 g) was obtained.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Bromo-2-chloro-3-fluorobenzene, and friends who are interested can also refer to it.
Reference:
Patent; KWANSEI GAKUIN EDUCATIONAL FOUNDATION; JNC CORPORATION; HATAKEYAMA, TAKUJI; MASUDA, KATSUYA; YAMAGA, YUKO; YANAI, MOTOKI; (214 pag.)TW2019/4977; (2019); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics