Related Products of 1716-42-3, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1716-42-3, name is 1-(3-Chloropropoxy)-4-fluorobenzene, This compound has unique chemical properties. The synthetic route is as follows.
EXAMPLE 14 N-Methyl-N-(4-(4-(1-(3-(4-fluorophenoxy)propyl)-1H-benzimidazol-2-yl-amino)piperidin-1-yl)-2-(3,4-dichlorophenyl)butyl)benzamide STR38 14.1 Synthesis of N-methyl-N-(4-(4-(1-(3-(4-fluorophenoxy)propyl)-1H-benzimidazol-2-yl-amino)piperidin-1-yl) -2-(3,4-dichlorophenyl)butyl)benzamide Combine N-methyl-N-(4-(4-(1H-benzimidazol-2-yl-amino)piperidin-1-yl)-2-(3,4-dichlorophenyl)butyl)benzamide (0.78 mmol), 1-chloro-3-(4-fluorophenoxy)propane (0.15 g, 0.78 mmol), benzyltriethylarnmonium chloride (0.01 g), sodium hydroxide (2.0 g), water (2 mL), and dichloromethane (4 mL). Heat to about 35° C. After 18 hours, add ethyl acetate (100 mL) and separate the layers. Extract the organic layer with aqueous saturated sodium bicarbonate and brine. Dry the organic layer over Na2 SO4, filter, and evaporate in vacuo to give the title compound.
The chemical industry reduces the impact on the environment during synthesis 1-(3-Chloropropoxy)-4-fluorobenzene. I believe this compound will play a more active role in future production and life.
Reference:
Patent; Hoechst Marion Roussel, Inc.; US5922737; (1999); A;,
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