Simple exploration of 4-Amino-3,5-dichlorobenzylamine

According to the analysis of related databases, 164648-75-3, the application of this compound in the production field has become more and more popular.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 164648-75-3, name is 4-Amino-3,5-dichlorobenzylamine, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 164648-75-3

(E)-tert-Butyl (4-amino-3,5-dichlorobenzylamino(amino)methylenecarbamate A mixture of 4-(aminomethyl)-2,6-dichlorobenzenamine (150 mg, 0.785 mmol), tert-butyl amino(methylthio)methylenecarbamate (157 mg, 0.825 mmol) and p-toluenesulfonic acid (142 mg, 0.825 mmol) in dichloromethane (4 mL) was stirred at rt for 2 days. The reaction mixture was concentrated under vacuum and purified by filtering through QAX anion exchange cartridge with methanol to provide the title compound as an off-white solid (260 mg, quantitative yield). 1H NMR (400 MHz, CD3OD) delta 1.453 (9H, s), 4.249 (2H, s), 7.162 (2H, s). HPLC retention time: 2.332 min (method A). MS (ESI) (M+H)+ 333.02.

According to the analysis of related databases, 164648-75-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Bristol-Myers Squibb Company; US2007/232581; (2007); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics