Electric Literature of 2533-69-9, A common heterocyclic compound, 2533-69-9, name is Methyl 2,2,2-trichloroacetimidate, molecular formula is C3H4Cl3NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a mixture of 2,3-diaminobenzonitrile (50.0 mg, 376 imol, 1.0 eq) in DCM (1 mL) was added methyl 2,2,2-trichloroethanimidate (86.1 mg, 488 imol, 1.3 eq), followed by the addition of TFA (107.0 mg, 939 imol, 2.5 eq). The mixture was stirred at 18C for 2 hours under N2 atmosphere. The mixture was diluted with 5 mL of DCM and filtered. The filtrate wasused directly into the next step without further purification. The 97.8 mg of cmde 2- (trichloromethyl)-1H-benzo[djimidazole-4-carbonitrile in 5 mL of DCM was obtained as a brown solution and used in the next step directly.
The synthetic route of 2533-69-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; AQUINNAH PHARMACEUTICALS, INC.; BURNETT, Duane, A.; VACCA, Joseph, P.; (310 pag.)WO2018/119395; (2018); A1;,
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