Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1005-56-7, name is O-Phenyl carbonochloridothioate, This compound has unique chemical properties. The synthetic route is as follows., COA of Formula: C7H5ClOS
194.2 mg (1.0 mmol) of methyl alpha-D-glucopyranoside, 41.6 mg (0.10 mmol) of dioctyl dichloro tin, tetrabutylammonium iodide36.9 mg (0.10 mmol) and 10 ml of tetrahydrofuran were added and stirred. To this mixed solution, 0.175 ml (1.3 mmol) of phenyl chlorothionoformate was added, then 0.271 ml (1.5 mmol) of 1,2,2,6,6-pentamethylpiperidine was added and the mixture was stirred at 20 C. for 6 hours.After completion of the reaction, 20 ml of a saturated aqueous solution of ammonium chloride was added to the reaction solution, and extraction operation was carried out three times with 20 ml of ethyl acetate. The organic phase (ethyl acetate phase) was washed with 20 ml of water and 20 ml of an aqueous sodium chloride solution, dried over anhydrous magnesium sulfate, filtered, and the solvent (ethyl acetate) was distilled off under reduced pressure. The residue was purified by silica gel chromatography (developing solvent n-hexane: ethyl acetate = 5:: 1), 319.5 mg (yield: 97%) of methyl 2-O-phenoxythiocarbonyl-alpha-D-glucopyranoside was obtained.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 1005-56-7.
Reference:
Patent; NAGASAKI UNIVERSITY; TOKUYAMA CORPORATION; ONOMURA, OSAMU; MURAMATSU, WATARU; TANIGAWA, SATOKO; IWASAKI, FUMIAKI; (19 pag.)JP5669637; (2015); B2;,
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