These common heterocyclic compound, 67952-93-6, name is 3-Chloro-4-methylbenzylamine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. HPLC of Formula: C8H10ClN
General procedure: A mixture of 2-amino-3-nitrobenzoic acid (5.0 mmol), EDCI (6.0 mmol),and HOBt (0.6 mmol) in DCM (30 mL) was stirred at room temperature for 5 mins. Then, amines (6.0 mmol) were added and the reaction was stirred at room temperature overnight. After completion, the mixture was diluted with DCM, washed with water twice, dried over anhydrous Na2SO4, evaporated, and chromatographed (EtOAc – petroleum ether) to afford the compounds 2a-k.
The synthetic route of 3-Chloro-4-methylbenzylamine has been constantly updated, and we look forward to future research findings.
Reference:
Article; Chen, Yinbo; Le, Vanminh; Xu, Xiaoyong; Shao, Xusheng; Liu, Jianwen; Li, Zhong; Bioorganic and Medicinal Chemistry Letters; vol. 24; 16; (2014); p. 3948 – 3951;,
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