Application of 698-01-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 698-01-1 name is 2-Chloro-N,N-dimethylaniline, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
General procedure: A mixture of benzoyl chloride 1a (0.5 mmol), N,N-dimethylaniline 2a (1.5 mmol), KMnO4 (1.5 equiv.) and CH3CN (2.0 mL) was placed in a 25 mL reaction straight tube under air atmosphere. The tube was then placed in an oil bath, stirred and heated at 60 C for 6 h. After cooling to room temperature, the system was flushed to Sand core funnel using dichloroethane (rinsing three times, VDCM < 50 mL), Vacuum filtration, and the volatile solvent was removed in vacuo. The crude product was purified through a silica gel column (ethyl acetate/petroleum ether = 1:5) to afford (93%) a yellow liquid.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Chloro-N,N-dimethylaniline, and friends who are interested can also refer to it.
Reference:
Article; Zhang, Zhang; Liu, Yong-Hong; Zhang, Xi; Wang, Xi-Cun; Tetrahedron; vol. 75; 19; (2019); p. 2763 – 2770;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics