Electric Literature of 102-49-8,Some common heterocyclic compound, 102-49-8, name is 3,4-Dichlorobenzylamine, molecular formula is C7H7Cl2N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A solution of 5-(hydroxymethyl)furfural (300 mg, 2.38 mmol) in methanol (10 mL) was treated with 3,4-dichlorobenzylamine (539 mg, 3.06 mmol), and the mixture stirred at rt for 5 hr. Sodium borohydride (158 mg, 4.18 mmol) was then added, and the solution was left to stir for 1 hr. The methanol was removed in vacuo and the residue dissolved in water (30 mL) extracted with dichloromethane (30 mL). The aqueous layer was further extracted with dichloromethane (2 x 30 mL) and the combined organic layers were dried over magnesium sulfate and concentrated in vacuo. The crude product was purified by flash column chromatography on aluminium oxide eluting with dichloromethane: methanol (98:2) to yield the product as an orange oil (635 mg, 93percent).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3,4-Dichlorobenzylamine, its application will become more common.
Reference:
Article; Brear, Paul; North, Andrew; Iegre, Jessica; Hadje Georgiou, Kathy; Lubin, Alexandra; Carro, Laura; Green, William; Sore, Hannah F.; Hyvoenen, Marko; Spring, David R.; Bioorganic and Medicinal Chemistry; vol. 26; 11; (2018); p. 3016 – 3020;,
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