Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 106131-61-7, name is 3,6-Dichloro-1,2,4,5-tetrazine, A new synthetic method of this compound is introduced below., Application In Synthesis of 3,6-Dichloro-1,2,4,5-tetrazine
General procedure: To a solution of DIPEA (2.1 mmol) in acetonitrile (150 mL) which was preheated to 70 C was added dropwise a solution of 3,6-dihydroxyphthalimide derivatives 1a-e (1 mmol) and 3,6-dichlorotetrazine (2, 1 mmol) in acetonitrile (25 mL) during 25 min. After being stirred for another 5 min, the reaction was quenched by cooling down the mixture to ambient temperature and adding water (200 mL). The resulting mixture was neutralized with dilute hydrochloric acid (1 M) and extracted with EtOAc (3 × 150 mL). The combined organic solution was washed with brine (3 × 200 mL) and then dried over anhydrous Na2SO4. After filtration and concentration, the residue was chromatographed on a silica gel column using a mixture of DCM and EtOAc (v/v = 100:1) as an eluent to give product 3a-e. 3a: 140 mg, yield 42%, red solid, mp 275 C (decomp.);1H NMR (400 MHz, acetone-d6, 25 C) delta 8.00 (s, 6H),7.20-7.34 (m, 15H); 13C NMR (101 MHz, acetone-d6, 25 C) delta168.8, 164.4, 147.1, 132.2, 132.1, 129.6, 128.8, 127.5, 125.6;IR (KBr, cm-1) nu: 3078, 1777, 1724, 1494, 1384, 1230, 1115,955; HRMS-APCI: [M + H]+ calcd for C48H22N15O12,1000.1567; found, 1000.1553; anal. calcd for C48H21N15O12:C, 57.66; H, 2.12; N, 21.01; found: C, 57.71; H, 2.08; N, 20.70.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Gu, Meng-Di; Lu, Yao; Wang, Mei-Xiang; Beilstein Journal of Organic Chemistry; vol. 15; (2019); p. 1976 – 1983;,
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