Electric Literature of 1127-85-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1127-85-1 name is 2,4-Dichloro-5,6,7,8-tetrahydroquinazoline, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
General procedure: To the solution of compounds 22 (0.3 g, 1.5 mmol) in DMF wereadded K2CO3 (1.95 mmol) and 4-amino-1-Boc-piperidine (2.7 mmol). The reaction was stirred at 80 C for 8 h. Then the mixture was extractedwith ethyl acetate, washed with brine, dried over MgSO4, andevaporated. The residue was purified by column chromatography togive the product (0.5 g, 92% yield).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2,4-Dichloro-5,6,7,8-tetrahydroquinazoline, and friends who are interested can also refer to it.
Reference:
Article; Fang, Yuanying; Xiong, Lijuan; Hu, Jianguo; Zhang, Shaokun; Xie, Saisai; Tu, Liangxing; Wan, Yang; Jin, Yi; Li, Xiang; Hu, Shaojie; Yang, Zunhua; Bioorganic Chemistry; vol. 86; (2019); p. 103 – 111;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics