Application of 72934-36-2, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 72934-36-2 as follows.
Step 3: iPr2NEt (0.35 g) was added into the solution of methyl 4-(4-chloro-6-(2,2,2- trifluoroethoxy-D2)- 1,3,5 -triazin-2-ylamino)benzoate (1 g) and 1 -(4- chlorophenyl)cyclopropanamine (0.46 g) in THF (15 mL). The reaction was stirred at70C for 16 hours. Solvents were removed under vacuum to give a residue, to which 100 ml of EtOAc were added. The organic phase was washed with water (2 x 20 mL) and brine (15 mL), dried over Mg504 and concentrated under vacuum to give methyl 4-(4-(1- (4-chlorophenyl)cyclopropylamino)-6-(2,2,2-trifluoroethoxy-D2)- 1,3 ,5-triazin-2- ylamino)benzoate (1.30 g) which was used in the further reaction without purification.
According to the analysis of related databases, 72934-36-2, the application of this compound in the production field has become more and more popular.
Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; WANG, Tao; YIN, Zhiwei; ZHANG, Zhongxing; SCOLA, Paul Michael; WO2014/116766; (2014); A1;,
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