In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 461432-23-5, name is 4-Bromo-1-chloro-2-(4-ethoxybenzyl)benzene belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Application In Synthesis of 4-Bromo-1-chloro-2-(4-ethoxybenzyl)benzene
Step 8: (3R, 4R, 5R) -3, 4, 5-tris (benzyloxy) -6- (benzyloxymethyl) -2- (4-chloro-3- (4-ethoxybenzyl) phenyl) tetrahydro-2H-pyran-2-ol (19h) To an ice-cold solution of compound 19g (540 mg, 1.0 mmol) in anhydrous THF (10 mL) was added a solution of (4-chloro-3- (4-ethoxybenzyl) phenyl) magnesium bromide in anhydrous THF (10 mL) , which was prepared freshly from 4-bromo-1-chloro-2- (4-ethoxybenzyl) benzene (486 mg, 1.5 mmol) and magnesium (54 mg, 2.25 mmol) . The reaction mixture was then allowed to stir at room temperature overnight, then quenched with saturated NH4Cl aqueous solution (10 mL) and extracted with ethyl acetate (2×40 mL) . The combined organic phase was washed with H2O (10 mL) , brine (10 mL) , dried (Na2SO4) , and concentrated to produce a residue, which was purified by column chromatography (200300 mesh silica gel, eluted with EtOAc/PE 1:20-1:10) to give compound 19h as a white solid (150 mg, 20) LC-MS (ESI) : 803.36 [M+NH4]+.
The synthetic route of 461432-23-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING; ZHANG, Zhiyuan; HUANG, Shaoqiang; ZHANG, Zhaolan; SU, Yaning; REN, Yan; (73 pag.)WO2016/41470; (2016); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics