Adding a certain compound to certain chemical reactions, such as: 53531-69-4, name is (4-Bromophenyl)methanesulfonyl chloride, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 53531-69-4, COA of Formula: C7H6BrClO2S
To a stirred mixture of potassium carbonate (74.8 g, 0.542 mol) in DCM (70 mL) and H20 (220 mL) at -10C was added pyrrolidine (21.2 g, 0.298 mol) in portions, and the resulting mixture was stirred for 20 min. Then (4-bromophenyl)methanesulfonyl chloride(73.0 g, 0.271 mol) in DCM (400 mL)was added drop-wise. The resultant mixture was stirred for 1 h at RT. The organic phase was separated, washed with H20, brine, dried over Na2S04, and concentrated in vacuo. The residue was recrystallized from 5% EtO Ac/petroleum ether to give the title compound. 1H NMR (300 MHz, CDC13) delta: 7.52 (d, 2H), 7.25 (d, 2H), 4.20 (s, 2H), 3.20-3.30 (m, 4H), 1.80-1.92 (m, 4H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, (4-Bromophenyl)methanesulfonyl chloride, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; MERCK SHARP & DOHME CORP.; CHILDERS, Matthew Lloyd; DINSMORE, Christopher; FULLER, Peter; GUERIN, David; KATZ, Jason David; PU, Qinglin; SCOTT, Mark E.; THOMPSON, Christopher F.; ZHANG, Hongjun; FALCONE, Danielle; TORRES, Luis; BRUBAKER, Jason; ZENG, Hongbo; CAI, Jiaqiang; DU, Xiaoxing; WANG, Chonggang; BAI, Yunfeng; KONG, Norman; LIU, Yumei; ZHENG, Zhixiang; WO2014/146490; (2014); A1;,
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