Reference of 13526-66-4, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 13526-66-4 as follows.
Synthesis of intermediate IV-02IV-01 IV-02To a solution of 3-bromo-6-chIoroimidazo[1 ,2-b]pyridazine (IV-01) (450 mg, 1.936 mmol) in 1 ,4-dioxane (8 mL) was added 3-(N-Boc-aminomethyl)pyridine-5- boronic acid pinacol ester (679 mg, 2.033 mmol), aq. Na2C03 2 (3 mL, 6 mmol) and PdCI2(PPh3)2 (136 mg, 0.194 mmol). The resulting mixture was heated at 80 C in a sealed tube for 8 h. On cooling, the mixture was diluted with DC and water. Layers were separated and the aqueous phase was extracted twice with DCM. The combined organic extracts were dried (Na2S04), filtered and concentrated. The residue was purified by flash chromatography (Biotage) using MeOH:DCM 0:100 to 20:80 as eluent to afford intermediate IV-02 (525mg, 75%).
According to the analysis of related databases, 13526-66-4, the application of this compound in the production field has become more and more popular.
Reference:
Patent; CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS (CNIO); PASTOR FERNANDEZ, Joaquin; ALVAREZ ESCOBAR, Rosa Maria; RIESCO FAGUNDO, Rosario Concepcion; GARCIA GARCIA, Ana Belen; RODRIGUEZ HERGUETA, Antonio; MARTIN HERNANDO, Jose Ignacio; BLANCO APARICIO, Carmen; CEBRIAN MUNOZ, David Alvaro; WO2012/156756; (2012); A2;,
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