Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1435-48-9, name is 2,4-Dichloro-1-fluorobenzene, A new synthetic method of this compound is introduced below., Safety of 2,4-Dichloro-1-fluorobenzene
2,4-dichlorofluorobenzene 165g (1mol) and Catalyst Cat.1 0.77g were added to the reaction flask.Warm up to 40 C,Further introducing CO2 to 2 MPa, and stirring the reaction for 3 hours to obtain a reaction liquid;Further, 15.4 g (0.1 mol) of CCl4 was added dropwise to the reaction liquid, and the temperature was raised to 60 C.Insulation reaction for 2 hours,The hydrogen chloride formed by the reaction is absorbed by the falling film, and after the reaction is completed,The material obtained by the reaction is filtered to recover Catalyst Cat.1, and the filtrate is distilled under reduced pressure.2,4-dichloro-5-fluorobenzoyl chloride 44.95g,The yield was 98.8%.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Zhejiang Ben Li Technology Co., Ltd.; Gu Haining; Wu Zhengjie; Yu Yongzhi; Xu Hongshun; (10 pag.)CN109553524; (2019); A;,
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