Sources of common compounds:

Reference of 918538-05-3,Some common heterocyclic compound, 918538-05-3, name is 2,4-Dichloropyrrolo[2,1-f][1,2,4]triazine, molecular formula is C6H3Cl2N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 1; 2-(4-(3-Cyclopropyl-l/f-pyrazol-5-ylamino)pyrrolo[l,2-fJ[l,2,4]triazin-2-yl)- lambda-(6-fluoropyridin-3-yl)pyrazolidine- 1 -carboxamide IA. 2-Chloro-N-(3 -cyclopropyl- lH-pyrazol-5-yl)pyrrolo [ 1 ,2-f] [ 1 ,2,4]triazin-4- amine [00146] A mixture of 2,4-dichloropyrrolo[l,2-f][l,2,4]triazine (977 mg, 5.2 mmole), S-cyclopropyl-lH-pyrazoW -amine (640 mg, 1 equiv), and diisopropylethylamine (1.54 mL, 1.7 equiv) in isopropyl alcohol (5 mL) was stirred at room temperature overnight. The product was collected by filtration (1.18 gm, 83% yield): MS: 275 (M+eta)~; HPLC Ret Time: 1.56 min. (Phenomenex-Luna s 10 3.0 x 50 mm column, 3 min gradient, 4 mL/min).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2,4-Dichloropyrrolo[2,1-f][1,2,4]triazine, its application will become more common.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; WO2009/111531; (2009); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics