Related Products of 93765-83-4, The chemical industry reduces the impact on the environment during synthesis 93765-83-4, name is 1-Bromo-5-chloro-2-fluoro-4-methylbenzene, I believe this compound will play a more active role in future production and life.
A mixture of 1-bromo-5-chloro-2-fluoro-4-methylbenzene (5.0 g, 23 mmol), copper(I) cyanide (4.0 g, 45 mmol) and copper(I) iodide (8.6 g, 45 mmol) in NMP (50 mL) was heated at 140C over night. After cooling to room temperature, the mixture was filterted and the filtrate was diluted with water (100 mL) and extracted with ethyl acetate (100 mL chi 3). The combined organic layers were washed with water (100 mL) and dried over Na2SO4. The solvent was removed and the residue was purified by SGC (eluting with petroleum ether/EtOAc = 10/1) to afford 5-chloro-2-fluoro-4-methylbenzonitrile (1.7 g, 45% yield) as a white solid
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Bromo-5-chloro-2-fluoro-4-methylbenzene, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; GENENTECH, INC.; XENON PHARMACEUTICALS INC.; CHEN, Chien-An; CHOWDHURY, Sultan; DEHNHARDT, Christoph Martin; SUN, Shaoyi; WO2014/144545; (2014); A2;,
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