In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 118-69-4, name is 2,6-Dichlorotoluene belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Formula: C7H6Cl2
Sub-step 1.1: In a 3000mL three-necked flask, add solid sodium methoxide 450g and dimethyl sulfoxide 700g, stir and heat up to 180 , start dropwise addition of 2,6-dichlorotoluene 1000g, after 4h dropwise addition, keep the reaction 2 hours, transfer to a distillation flask, distill dimethyl sulfoxide under reduced pressure through a rectification column (applied in the next batch), and distill under reduced pressure for 5 hours at a temperature of 130 C and a pressure of -0.095MPa.Distilled substrate.Substep 1.2: Transfer the distillation substrate to a three-necked flask, add 80g of dimethyl sulfate dropwise at 80 C, complete the dropwise addition within 2h, hold the reaction for 1.5 hours, add 1500g of water, and after washing, transfer the oil layer to the distillation flask. Distillation under reduced pressure for 8 hours at a temperature of 120 C and a pressure of -0.095MPa,906.1g of 2-methyl-3-chloroanisole was obtained.
The synthetic route of 118-69-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Xi’an Zhengyang Jiahe Chemical Technology Co., Ltd.; Guo Xiangxiang; (8 pag.)CN111018693; (2020); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics