108-37-2, name is 1-Bromo-3-chlorobenzene, belongs to chlorides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: 108-37-2
General procedure: The substituted aryl bromide (1.0 mmol), 8-hydroxyquinoline (20 mol%) and KOtBu (2.0 mmol) were loaded into a Schlenk tube equipped with a Teflon-coated magnetic stir bar. The unactivated arene (8.0 mL or 80 equiv) was then added and the mixture was stirred at r.t. for 3-5 min. The Schlenk tube was placed in a preheated oil bath at 80 C and the mixture was stirred for 18 h. After completion of the reaction as judged by GC analysis, the Schlenk tube was allowed to cool to r.t. and the contents quenched with H2O and diluted with EtOAc. The organic layer was separated, and the aqueous layer was extracted with EtOAc. The combined organic layer was dried over Na2SO4 and concentrated under reduced pressure. The crude residue was purified by flash column chromatography on silica gel to afford the desired biaryl product.
The synthetic route of 108-37-2 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Zheng, Xuehua; Wu, Xu-Nian; Chen, Jing-Yi; Luo, Hai-Bin; Wu, Deyan; Wu, Yinuo; Synthesis; vol. 50; 8; (2018); p. 1721 – 1727;,
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