Reference of 367-22-6,Some common heterocyclic compound, 367-22-6, name is 4-Chloro-3-fluoroaniline, molecular formula is C6H5ClFN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
[0075] 4-Chloro-3-fluoroaniline (2g, 13.7 mmol) was dissolved in 60 mL of dichloromethane.Under ice bath, saturated sodium bicarbonate solution (60 mL) was added. The mixture wasstirred at 0 C and triphosgene (1.36g, 4.58 mmol) was added. The mixture was stirred at 0 C for1 h and then extracted with dichloromethane and water. The organic layer was dried with sodiumsulfate and filtered. The filtrate solution was concentrated and the residue was treated with 50mL ofhexanes. The hexane solution was concentrated to remove all solvents. The residue wastaken up in 12 mL ofhexanes and filtered. The solution was concentrated and dried to give 1-chloro-2-fluoro-4-isocyanatobenzene as an offwhite solid (1.69 g). 1H NMR (400 MHz,CHLOROFORM-d) 8 ppm 6.82- 6.90 (m, 1 H) 6.93 (dd, J=9.22, 2.65 Hz, 1 H) 7.31 – 7.41 (m, 1H)
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-Chloro-3-fluoroaniline, its application will become more common.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; BROTHERTON-PLEISS, Christine, E.; CHEN, Zhi; ERICKSON, Shawn, David; KIM, Kyungjin; LI, Hongju; QIAN, Yimin; SO, Sung-Sau; WOVKULICH, Peter, Michael; YI, Lin; WO2014/56958; (2014); A1;,
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