Adding a certain compound to certain chemical reactions, such as: 626-43-7, name is 3,5-Dichloroaniline, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 626-43-7, Recommanded Product: 3,5-Dichloroaniline
Step 1 Preparation of #-(3,5-dichlorophenyl)-2-hydroxyimino-acetamide To a solution of 3,5-dichloroanilin (10.0 g, 61.7 mmol) in purified water were added conc. hydrochloric acid (12 ml) and 1,4-dioxane (20 ml), and the resulting mixture was heated until it became transparent, followed by the addition of a 50 C. solution of chloral hydrate (10.5 g, 66.9 mmol) and Na2SO4 (66.0 g) in purified water (224 ml) thereto. Then, the resulting mixture was added to a solution of hydroxylamine hydrochloride (13.0 g, 180 mmol) in water (60 ml) and heated for 50 min with flux. After the mixture was cooled to room temperature, the insoluble solid was filtered, washed with distilled water, and dried in a vacuum to afford the title compound as a pale solid (12.8 g, 89%). TLC Rf=0.5 (ethylacetate:n-hexane=1:3); m.p. 196-197 C.; 1H NMR (DMSO-d6) delta 7.39 (t, 1H, J=1.8 Hz, ArH), 7.70 (s, 1H, CHNOH), 7.89 (d, 2H, J=1.8 Hz, ArH), 10.54 (br s, 1H, NH), 12.40 (br s, 1H, NOH); MS (EI) m/e 233 [M+], 216, 202, 189, 161.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3,5-Dichloroaniline, and friends who are interested can also refer to it.
Reference:
Patent; Korea Research Institute of Chemical Technology; US2009/203708; (2009); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics