Synthetic Route of 54932-72-8, A common heterocyclic compound, 54932-72-8, name is 4-Bromo-1-chloro-2-methylbenzene, molecular formula is C7H6BrCl, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A solution of 4.1 g (20 mmol) of 5-bromo-2-chlorotoluene, 0.66 g (4 mmol) of 2,2-azobisisobutyronitrile, 3.9 g (22 mmol) of N-bromosuccinimide and 20 ml of chloroform Dry two bottles, reflux 5h.(100 ml), dried over anhydrous sodium sulfate, filtered, concentrated under reduced pressure, and the residue was recrystallized from ethanol to give 4.1 g of needle-like crystals (100 ml), washed with water (100 ml) (Yield 72%).
The synthetic route of 54932-72-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; China Pharmaceutical University; XUE, XIAO WEN; LIU, LIN YI; LONG, JIN JIE; SONG, YA JING; LI, JIA BIN; (7 pag.)CN104478670; (2016); B;,
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