Adding a certain compound to certain chemical reactions, such as: 39226-96-5, name is (2-Chloro-3-(trifluoromethyl)phenyl)methanamine, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 39226-96-5, Recommanded Product: (2-Chloro-3-(trifluoromethyl)phenyl)methanamine
(v) To a stirred suspension of 1-(1-{[(1 ,1-dimethylethyl)oxy]carbonyl}-4-piperidinyl)-3- methyl-2-oxo-4-imidazolidinecarboxylic acid (0.55 mmol) in dichloromethane (10 ml) was added 1-hydroxybenzotriazole hydrate (89 mg, 0.66 mmol), 1-ethyl-3-(3- dimethylaminopropyl)carbodiimide hydrochloride (127 mg, 0.66 mmol) and N-ethyl morpholine (0.21 ml, 1.65 mmol) and the mixture was stirred at room temperature for 15 minutes. A solution of {[2-chloro-3-(trifluoromethyl)phenyl]methyl}amine (1 15 mg, 0.55 mmol) was added and the reaction was stirred at room temperature for 3 hours. The reaction was diluted with dichloromethane and the solution was washed with saturated sodium hydrogen carbonate solution, water, citric acid solution, water and brine, dried and evaporated. The residue was purified by silica gel chromatography eluting with 5-10% methanol in dichloromethane to give 1 ,1-dimethylethyl 4-{4-[({[2- chloro-3-(trifluoromethyl)phenyl]methyl}amino)carbonyl]-3-methyl-2-oxo-1- imidazolidinyl}-1-piperidinecarboxylate (243 mg, 85%), LC/MS [M+H]+ = 519, retention time = 2.89 minutes.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, (2-Chloro-3-(trifluoromethyl)phenyl)methanamine, and friends who are interested can also refer to it.
Reference:
Patent; GLAXO GROUP LIMITED; WO2008/119825; (2008); A2;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics