Some scientific research about 102-49-8

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3,4-Dichlorobenzylamine, other downstream synthetic routes, hurry up and to see.

Application of 102-49-8, The chemical industry reduces the impact on the environment during synthesis 102-49-8, name is 3,4-Dichlorobenzylamine, I believe this compound will play a more active role in future production and life.

Example 19.7: Preparation of 2-BenzyIoxy-5-morpholin-4-yl-l-oxo-lH-9-oxa-4,9oe- diaza-fluorene-3-carboxylic acid 3,4-dichloro-benzylamidelambdazetalambdaf’-Dicyclohexylcarbodiimide (110 mg, 0.522 mmol) was added to a stirred solution of the product from Example 19.6 (200 mg, 0.475 mmol) in dichloromethane (100 mL), After 30 min, lambdazetaN-dimethylaminopyridine (6 mg, 0.05 mmol), 3,4- dichlorobenzylamine (92 mg, 0.52 mmol) and 1-hyroxybenzotriazole (70 mg, 0.52 mmol) were added successively. The mixture was stirred at room temperature overnight and aqueous work-up and extraction afforded the crude product was further purified by column chromatography (hexane/ethyl acetate 4:1) as eluent to afford the desired product (120 mg, 44 percent) as a yellow solid.1H NMR (300 MHz, CDCl3) delta 3.37-3.45 (m, 4H), 3.85-3.95 (m, 4H), 4.51 (d, J=5.8 Hz, 2H), 5.43 (s, 2H), 6.84 (d, J=8.3 Hz, IH), 7.06-7.16 (m, 2H), 7.28-7.36 (m, 3H), 7.37-7.49 (m, 4H), 7.55-7.71 (m, 2H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3,4-Dichlorobenzylamine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; AVEXA LIMITED; WO2008/77188; (2008); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics