Adding a certain compound to certain chemical reactions, such as: 6940-78-9, name is 1-Bromo-4-chlorobutane, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 6940-78-9, Computed Properties of C4H8BrCl
Thiophenol (1.0 g, 9.1 mmol) was added toa solution of NaOH (0.36 g, 9.1 mmol) in a mixture solvent of EtOH and H2O (1: 1 (v/v), 65 mL) with vigorous stirring. After 10 min, 1-bromo-4-chlorobutane (1.15 mL, 10.0 mmol) was added and the mixture was reacted at room temperature for 8 h. The volatile species were removed under reduced pressure. The residue was then extracted with Et2O (320 mL) and the combined organic layers were dried over anhydrous Na2SO4 and concentrated to dryness to give 1.5 g of (4-chlorobutylsulfanyl)benzene as a yellow oil (7.5 mmol, 82%). Next, AgOTf (1.8 g, 7.0 mmol) was added to a solution of (4-chlorobutylsulfanyl)benzene (1.4 g, 7.0 mmol) in ClCH2CH2Cl (30 mL) and reacted at room temperature in the darkness for 8 h. The gray precipitates were removed and the solution was treated with anhydrous Na2SO4 and filtered. The filter cake was washed by ClCH2CH2Cl (35 mL). The combined filtrates were concentrated under reduced pressure to give a viscous yellow oil, which was further washed by Et2O to provide 2.1 g of [PhS(CH2)4][OTf] (2l) as a white solid (6.7 mmol, 96%). Mp 44-45 C. 1H NMR (400 MHz, CDCl3) d 7.80 (dm, J7.1 Hz, 2H),7.72-7.63 (m, 3H), 4.20 (dt, J13.4, 7.0 Hz, 2H), 3.69 (dt, J12.3,6.1 Hz, 2H), 2.59-2.52 (m, 4H). 19F NMR (376 MHz, CDCl3) d 78.3(s, 3F). 13C NMR (126 MHz, CDCl3) d 134.1 (s), 131.3 (s), 129.8 (s),125.9 (s), 120.7 (q, J320.3 Hz), 48.5 (s), 29.1 (s). IR (KBr): 3093,3015, 2957, 2878, 2287, 1582, 1484, 1447, 1423, 1266, 1223, 1160,1078, 1030, 1001, 894, 876, 749, 686, 638, 573, 517 cm1. ESI-MS (m/z): 165.1 ([M]). Anal. Calcd for C11H13F3O3S20.5H2O: C 40.86, H4.36; Found: C 40.60, H 4.45.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Bromo-4-chlorobutane, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Wang, Xiao-Yan; Song, Hai-Xia; Wang, Shi-Meng; Yang, Jing; Qin, Hua-Li; Jiang, Xin; Zhang, Cheng-Pan; Tetrahedron; vol. 72; 47; (2016); p. 7606 – 7612;,
Chloride – Wikipedia,
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