Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 102-49-8, name is 3,4-Dichlorobenzylamine, A new synthetic method of this compound is introduced below., Formula: C7H7Cl2N
General procedure: To a Schlenk tube were added benzylamine 1 (1.3 mmol), indole 2(2.0 mmol), Fe(OTf)2 (10 molpercent), and anhydrous chlorobenzene (2 mL).The tube was equipped with an O2 balloon, and the mixture wasstirred at 110 °C until complete consumption of indole (TLC monitoring).When the reaction was complete, the mixture cooled to r.t., dilutedwith CH2Cl2 (10 mL), and washed with H2O (2 × 10 mL). The organicextract was dried (anhyd Na2SO4) and concentrated under reducedpressure, and the resulting residue was purified by columnchromatography (silica gel, hexane?EtOAc) to afford the correspondingbis(indolyl)methane products 3 and 4.
The synthetic route of 102-49-8 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Gopalaiah, Kovuru; Chandrudu, Sankala Naga; Devi, Alka; Synthesis; vol. 47; 12; (2015); p. 1766 – 1774;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics