Application of 94-97-3,Some common heterocyclic compound, 94-97-3, name is 5-Chloro-1H-benzo[d][1,2,3]triazole, molecular formula is C6H4ClN3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: Styrene (1.0 equiv.) in anhydrous dichloromethane (5 mL) and NBS (2.0 equiv.) was taken into RB and reaction mixture was stirred at room temperature. After 30 min benzotriazole (2.0 equiv) dissolved in anhydrous DCM was added drop wise to the reaction mixture. After the completion of reaction as monitored by TLC, solvent was evaporated under vacuum. The reaction mixture was extracted with ethyl acetate and washed with hypo and brine solution. The organic layer obtained was dried over sodium sulphate, filtered and then evaporated under reduced pressure. Further purification was done by using flash column chromatography (SiO2).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5-Chloro-1H-benzo[d][1,2,3]triazole, its application will become more common.
Reference:
Article; Bose, Priyanka; Singh, Anoop S.; Singh, Mala; Tiwari, Vinod K.; Tetrahedron; (2020);,
Chloride – Wikipedia,
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