Electric Literature of 118-69-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 118-69-4 name is 2,6-Dichlorotoluene, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
235.0 g (3.0 mol) of acetyl chloride were added dropwise with stirring at 100 C. in the course of 2 hours to a solution of 502.0 g (3.12 mol) of 2,6-dichlorotoluene and 408.0 g (3.06 mol) of aluminum trichloride. After the mixture had been stirred for 2 hours at 100-105 C. it was cooled, and the reaction mixture was poured onto 3 l of ice and 1 l of water. The solid which had precipitated during this process was filtered off with suction and washed to neutrality with 800 ml of water. After drying at 40 C., 500.0 g of 2,4-dichloro-3-methylacetophenone were obtained as crude product, which were subsequently distilled under a high vacuum. (Boiling point: 121-128 C. (4 mbar))
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2,6-Dichlorotoluene, and friends who are interested can also refer to it.
Reference:
Patent; BASF Aktiengesellschaft; US6028035; (2000); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics