Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 108-41-8, name is 1-Chloro-3-methylbenzene, This compound has unique chemical properties. The synthetic route is as follows., category: chlorides-buliding-blocks
General procedure: In a glovebox with an N2 atmosphere, to a vial containing bis(pinacolato)diboron (0.6 mmol, 3 equiv.), complex 1 (8.5 mg, 0.01 mmol, 0.05 equiv.), potassium acetate (78.5 mg, 0.8 mmol, 4 equiv.), THF (1 mL), was added aryl chloride (0.2 mmol, 1 equiv.). The mixture was allowed to react at room temperature for 24-48 h. After quenching with water, the reaction mixture was extracted with ethyl acetate. The organic layer was washed with brine and then evaporated under vacuum. Flash chromatography on silica gel Flash chromatography on silica gel (hexane:ethyl acetate = 100:0 to 85:15) yielded the product.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 108-41-8.
Reference:
Article; Dong, Jie; Guo, Hui; Peng, Wei; Hu, Qiao-Sheng; Tetrahedron Letters; vol. 60; 11; (2019); p. 760 – 763;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics