Electric Literature of 62356-27-8, The chemical industry reduces the impact on the environment during synthesis 62356-27-8, name is 1-Bromo-3-chloro-2-methylbenzene, I believe this compound will play a more active role in future production and life.
Take a 500 ml double-necked round bottom bottle and place it in a stirrer with a reflux tube. After drying, it is filled with nitrogen. First, add compound A-1 (20.548 g, 1.0 equivalent) and NBS (N-bromosuccinimide). , 19.5778 grams, 1.1 equivalents),And AIBN (azobisisobutyronitrile, 0.821 g, 0.5 mol%), followed by the addition of carbon tetrachloride (250 ml) and stirred for 10 minutes.Finally heated to reflux and reacted for 24 hours;After warming-up, water (200 ml) was added, followed by extraction with ethyl acetate (3×200 ml), and the obtained extract was sequentially dried over magnesium sulfate, filtered and evaporated to dryness. Ethyl acetate/hexane, 1/10) gave Intermediate 1-1 (21.044 g, yield 74%).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Bromo-3-chloro-2-methylbenzene, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Ningbo Lumilan New Materials Co., Ltd.; Ningbo Jizhichuang New Materials Institute Co., Ltd.; Wei Dingwei; Xie Kunshan; Chen Zhikuan; (50 pag.)CN109651423; (2019); A;,
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