Electric Literature of 73006-78-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 73006-78-7, name is 5-Chloro-[1,1′-biphenyl]-2-amine belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
250 mL under a stream of nitrogenCompound 2-A (6.0 g, 29.46 mmol) in flask,1-naphthalene boronic acid (6.08 g, 35.35 mmol),Potassium triphosphate (15.63 g, 73.65 mmol),Palladium (II) acetate (0.198 g, 0.884 mmol),2-dicyclohexylphosphino-2 ‘, 6′-dimethoxybiphenyl (0.726 g, 1.767 mmol), toluene (100 mL) and H2O (10 mL) were added thereto, and the mixture was stirred and refluxed.After completion of the reaction, the toluene layer was extracted using toluene and water. The extracted solution was treated with MgSO 4 to remove residual water, concentrated under reduced pressure, and purified by column chromatography to give a compound 2-B.6.16 g was obtained in 70.8% yield.
The synthetic route of 5-Chloro-[1,1’-biphenyl]-2-amine has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Material Science Co.,Ltd.; Lee Tae-wan; Huh Jeong-hoe; Lee Dong-hun; Park Seong-min; Kim Seon-jae; Kim Seong-hun; (44 pag.)KR102041137; (2019); B1;,
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