These common heterocyclic compound, 202197-26-0, name is 3-Chloro-4-((3-fluorobenzyl)oxy)aniline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 202197-26-0
The 3.2g (12.7mmol) compound (VI compound of formula) and 6.4g (53.7mmol) DMF-DMA was added to 100mL eggplant Bottle, heated to reflux for 1h, evaporated under reduced pressure to remove excess DMF-DMA; glacial acetic acid was added 20mL (349.4mmol) and 3.4g (10.7mmol) 2-amino-5-[5-[[[2-(methanesulfonyl)ethyl]amino]methyl]furan-2-yl]benzonitrile (V), was heated under reflux IH; After the reaction system was cooled to room temperature and poured into 80mL of ice water, suction filtered, the filter cake washed with 80mL of methanol and 80mL of ice water Di, 60 C vacuum drying 8h, give lapatinib (a compound of Formula I) 5.1g (8.8mmol, molar yield of 82.4%, HPLC pure Of 99.3%).
The synthetic route of 3-Chloro-4-((3-fluorobenzyl)oxy)aniline has been constantly updated, and we look forward to future research findings.
Reference:
Patent; SHANGHAI ACEBRIGHT PHARMACEUTICAL CO., LTD; DAFENG ACEBRIGHT PHARMACEUTICALS CO., LTD; SHANGHAI ACEBRIGHT PHARMACEUTICALS GROUP CO., LTD.; AN, XIAOXIA; LYU, FENG; YAN, LI; WANG, GUANXING; GAI, HONGTAO; LI, HUICHAO; (12 pag.)CN103896889; (2016); B;,
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