Electric Literature of 20850-43-5, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 20850-43-5 as follows.
General procedure: Suspension of the appropriate 3-amino-1,1-dioxo-1,4,2-benzodithiazine derivative 4a-h (0.5 mmol), anhydrous K2CO3 (1.5 mmol, 0.21 g) and the appropriate alkyl chloride (0.6 mmol) in dry THF (5 ml) was heated at reflux for 20-24 h, then cooled in ice-bath and filtered off. The crude product was suspended in 5 ml of water, heated gently to ca. 50 C; and cooled with vigorous stirring until granular precipitate appeared. Filtering off and washing with cold water and diluted EtOH gave pure potassium salts. 4.5.10 ;N-{2-[(1,3-Benzodioxol-5-yl)methylthio]-4-chloro-5-(4-(4-chlorophenyl)thiazol-2-yl)benzenesulfonyl}cyanamide potassium salt (5n) ;Starting from 4f (0.221 g) and 1,3-benzodioxol-5-ylmethyl chloride (0.102 g). Yield: 0.234 g (76%): m.p. 260-262 C; IR (KBr): nu 2895, 2185, 1635, 1578, 1503, 1488, 1472, 1361, 1285, 1142 cm-1; 1H NMR (500 MHz, DMSO-d6): delta 4.32 (s, 2H, SCH2), 6.00 (s, 2H, OCH2O), 6.87-6.89 (m, 1H, Ar), 6.96-6.97 (m, 1H, Ar), 7.04 (s, 1H, Ar), 7.55-7.57 (m, 2H, Ar), 7.60 (s, 1H, Ar), 8.06-8.08 (m, 2H, Ar), 8.41 (s, 1H, Ar), 8.77 (s, 1H, Ar); Anal. C24H14Cl2KN3O4S3 (C, H, N).
According to the analysis of related databases, 20850-43-5, the application of this compound in the production field has become more and more popular.
Reference:
Article; Brozewicz, Kamil; Slawinski, Jaroslaw; European Journal of Medicinal Chemistry; vol. 55; (2012); p. 384 – 394;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics