Synthetic Route of 60811-21-4, A common heterocyclic compound, 60811-21-4, name is 4-Bromo-2-chloro-1-fluorobenzene, molecular formula is C6H3BrClF, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
The ary bromide (1.0 eq), aryboronc acid (1.1 eq), K2C03 (1.5 eq) and PdC2( PPh3)2 (5mo%), under an atmosphere of nitrogen, were suspended n a 1:1 THF:H20 mixture (4 mLper mmo). The reacUonwas heated to refiux and aflowed to stir overnight. The mixture wasthen cooed to room temperature and parUUoned between EtOAc and water, The organic ayer was washed with water, brine, dred over Na2SO4, ffltered, dry oaded onto sWca and purfied by coumn chromatography using sWca as the staDonary phase and a mxture of petroeum benzne/EtOAc as the &uent.() 3-Choro-4-fluoro-1,1bpheny was obtained by the Suzuki couphng method D from 1- bromo-3-choro-4-fluorobenzene as a pae yeflow oH that crystaWzed as an off-white sohdupon standing (43% yed). 1H NMR (400 MHz, CDC3) 67.60 (dd, J = 7.0, 2.3 Hz, 1H), 7.53-7.46(m, 2H), 7.44-7.41 (m, 3H), 7.38-7.35 (m, 1H), 7.19 (t, J = 8.7 Hz, 1H).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; MONASH UNIVERSITY; THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH; VOSS, Anne Kathrin; BAELL, Jonathan; NGUYEN, Huu Nghi; LEAVER, David J.; CLEARY, Benjamin L.; LAGIAKOS, H. Rachel; SHEIKH, Bilal Nadeem; THOMAS, Timothy John; (115 pag.)WO2016/198507; (2016); A1;,
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