In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1435-44-5 as follows. Application In Synthesis of 1-Chloro-2,4-difluorobenzene
(4) (2R, 3R)-(1,2,4 triazole)-2-chlorobutane 6 produced in the step (3)(6.8 g, 2.8 mol) was added 2,4-difluorobenzene chloride (8.2 g, 2.2 mol) and added50% sodium hydroxide solution (400ml) with quaternary ammonium salt tetrabutylammonium hydrogen sulfate and iron,Substitution reaction(2R,3R)-2-(2,4-difluorophenyl)-1-(1H-1,2,4triazol-1-yl)-2-chlorobutane 7(13.12g, 3.96mol)
According to the analysis of related databases, 1435-44-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Ren Wei; (7 pag.)CN108383829; (2018); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics